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Objective: To investigate the effect of flavones of buckwheat flower and leaf (FBFL) on the blood glucose fluctuations and influence of renal lesions in diabetic rats and to explore its possible mechanism.Methods: In vitro, the effects on a-glycosidase activity of different concentrations FBFL were tested; In vivo, the rats was assigned to the different concentrations FBFL-treated groups (100, 200, 400 mg/kg-1) and the positive drug Acarbose (ACAR 10mg kg-1) group.The fasting blood glucose (FBG) , the no fasting blood glucose (NFBG) , 24 h urinary protein excretion rate (24UAER), urine endogenous creatinine clearance rate (Ccr), blood and renal glycation endproducts (AGEs) were measured by suitable methods.Results: In vitro, FBFL inhibited significantly a-glycosidase activity in concentration-dependent; otherwise, in vivo, FBFL inhibited the increase of NFBG in diabetic rats, inhibition rate of the high doses of FBFL (400 mg/kg-1) was 62.09％, similar with that of ACAR (69.31%).Both of FBG and NFBG were reduced in FBFL treated diabetic rats; moreover, the reduction amplitude of NFBG (abrosia for 6h, 12h and 24h) was significantly lower.FBFL and ACAR also significantly reduced 24hUAER, increased urinary Ccr (P ＜0.01) in diabetic rats.Conclusion: FBFL have a stabilizing effect on blood glucose in diabetic rats, and it also can reduce or delay diabetic kidney damage.The mechanism may be through inhibiting the a-glycosidase activity and reducing the formation of AGEs.