【摘 要】
:
Fragment-based drug design (FBDD) has been proved to be a novel paradigm for small molecule drug discovery in the past decade.It has been established as the
【机 构】
:
Chemistry Research Labs Astellas Pharma Inc.Japan
【出 处】
:
中国上海第七届国际新药发明科技年会
论文部分内容阅读
Fragment-based drug design (FBDD) has been proved to be a novel paradigm for small molecule drug discovery in the past decade.It has been established as the principle altemative to traditional methods used for lead discovery in pharmaceutical companies,such as high-throughput screening (HTS) and virtual screening.In Astellas,we have introduced FBDD platform into lead discovery process in various drug discovery projects.Given the increasing demand for data regarding protein-ligand interaction,we acquired a priority access to a new high throughput synchrotron beamline AR-NE3A built in the Photon Factory Advanced Ring at High Energy Accelerator Research Organization in this April.We are now trying to take full advantages of a large number of complex structures and also combine FBDD with other technologies.In this work,we will describe the some aspects about application of FBDD including successful and unsuccessful experiences in Astellas.
其他文献
Herbs used in Traditional Chinese Medicine have been screened for compounds which may be active against four targets involved in inflammation,using pharmaco
他是20世纪后半期经过炼狱的燃烧仍追求完美,梦想着“飞天”的艺术家刘宇廉。没有多少人知道他的名字。然而,这里呈现给读者的是他的四卷本全集画集、日记、书信、文稿、友
金泽珊,一九七二年出生,九二年毕业于“中国书画函授大学”书法篆刻专业,中国书法家协会会员、黑龙江省书法家协会会员,哈尔滨清风硬笔书法培训中心创办人。书法作品参加:94
脐橙矮化密植早结丰产 ,即是采用矮化砧 ,改变栽植方式、控根、控冠 ,进行矮化密植 ,使之充分利用阳光和地力 ,达到早期结果 ,早期丰产的目的 ,已经引起了国内外的注意。江西
Long-term administration of L-3,4-dihydroxyphenilalanine (levodopa),the mainstay treatment for Parkinson s disease (PD),is accompanied by fluctuations in it
Cancer cells are characterized by the ability to grow in an anchorage-independent manner.The activity of the nonreceptor tyrosine kinase,focal adhesion kina
一个普通的中国女人,40多岁了,住在地球的那一端,却在最近引发了一场网络眼球风暴。 一组名为“冰雪裸舞”的照片开始在网上流传,照片上的她在皑皑白雪下舞动身躯,赤裸的身体只有薄薄的红纱相裹。 短短几天,她个人的页面就已累计10多万人次的点击率,有人赞,有人骂。 她是谁?她想干什么? “我不懂什么芙蓉姐姐” 贝琳达,原名姬晹。生长于江苏,工作则在山东。2000年同丈夫、儿子移居加拿大
Estrogen signaling is pivotal in normal development and physiology of bone,cardiovascular and neuronal systems.Inappropriate estrogen signaling is involved
红色张国荣我本是女娇娥,又不是男儿郎。这句话从张国荣嘴里道出,每每让人错觉。有着眉目如画的哥哥,虞姬的临去秋波那一转,六宫粉黛失色,如此绝色,才衬得起一个红字。红也
The ability of rapid gain in potency of compounds by structure based drug design together with the high sensitivity of biophysical methods like Surface Plas