Identification and functional analysis of a cerebellum highly expressed long noncoding RNA

来源 :第九届海内外华人神经科学家研讨会(The 9th Symposium for Chinese Neuroscientis | 被引量 : 0次 | 上传用户：passtestall

【摘要】

：

【作者】

：

Bowen Zhang Xiaolin Liang Xiaoyuan Song Xiangting Wang

【机构】

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CAS Key Laboratory of Brain Function and Disease,University of Science and Technology of China,Hefei

【出处】

：

第九届海内外华人神经科学家研讨会(The 9th Symposium for Chinese Neuroscientis

【发表日期】

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2016年3期

【关键词】

：

long noncoding RNA central nervous system cerebellum [

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　　Long noncoding RNAs are novel regulators in central nervous system.Here,we identified a cerebellum highly expressed lncRNA1-CeH-lncRNA1.Compared with olfactory bulb,hippocampus and hypothalamus, CeH-lncRNA1 was exclusively expressed in adult mouse cerebellum as the second highest expressed CeH-lncRNA among the 63 tested CeH-lncRNAs.Subcellular location assay showed that the majority of CeH-lncRNA1 was located in nucleus.Modulation of the CeH-lncRNA1 level in neuron 2a cells by lentiviral-based shRNA or overexpression greatly affected the mRNA levels of several cerebellum development associated genes including Cbln3 and Zic5,suggesting that CeH-lncRNA1 may play roles in mouse cerebellum development via transcriptional regulation.The in vivo role of CeH-lncRNA1 is currently under investigation.

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Identification and functional analysis of a cerebellum highly expressed long noncoding RNA

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