【摘 要】
：
无乳链球菌属于革兰氏阳性菌,亦称B群链球菌(Group B Streptococcus,GBS),是医学上重要的致病菌,致病力强,近年来GBS的感染率呈上升趋势,而且随着抗生素的大量使用,一些耐药问题也日益突出.一些关于放线菌菌株AF1的试验表明该菌株发酵液提取物对革兰氏阳性致病菌的抑制作用较好,有较强的稳定性.为了研究该菌株发酵液提取物对无乳链球菌的抑制作用及其最低抑菌浓度MIC (minima
【机 构】
：
华南农业大学天然源农药与化学生物学教育部重点实验室,广州,510642
【出 处】
：
第二届生物农药理论探索及产业化技术创新研讨会
论文部分内容阅读
无乳链球菌属于革兰氏阳性菌,亦称B群链球菌(Group B Streptococcus,GBS),是医学上重要的致病菌,致病力强,近年来GBS的感染率呈上升趋势,而且随着抗生素的大量使用,一些耐药问题也日益突出.一些关于放线菌菌株AF1的试验表明该菌株发酵液提取物对革兰氏阳性致病菌的抑制作用较好,有较强的稳定性.为了研究该菌株发酵液提取物对无乳链球菌的抑制作用及其最低抑菌浓度MIC (minimal inhibitory concentration),实验测试了加入AF1代谢粗提物后无乳链球菌的生长曲线,采用分光光度计法测量加入不同浓度AF1发酵液提取物后无乳链球菌菌悬液的吸光度,双倍稀释法测定杀菌作用,通过扫描电镜观察作用后的细胞,以此评价AF1代谢粗提物对无乳链球菌的抑菌性.结果 表明：粗提物对无乳链球菌有较好的抑菌作用和一定的杀菌效果,最低抑菌浓度均为30μg/mL.
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