The entire separation of the compounds of interest must always be a primary goal in any chromatographic process.Although single column chromatographic methodologies may often provide sufficient resolving power for the separation of target components in mediumly complex samples, many matrices present a complexity that exceeds the peak capacity of any monodimensional system.The direct consequence is that many elution bands will be the result of two or more overlapping analytes.Separation power may be increased consistently through the employment of a multidimensional set-up, which consists essentially in the hyphenation of two independent analytical steps.Conventional multidimensional gas chromatography (MDGC) enables the re-injection of multi-compound bands from a primary to a secondary column.The peak capacity of such a system becomes the sum of the peak capacity of the first dimension and that of the second dimension, the latter multiplied by the number of cuts.Whenever the complete resolution of only a number of effluent bands is requested, conventional MD chromatography is certainly a prime choice, as these systems are usually characterized by two dimensions of comparable resolving power.