近年来,由于短期生物测试的发展,国外对染发剂的致癌、致突变、致畸变研究日益增多。Chester Beatty癌症研究所和加利福尼亚大学的学者们发现许多染发药水都能损害鼠伤寒沙门氏菌的遗传物质DNA。Ames氏实验室的结论认为85％的氧化型染发剂具有致突变作用。然而,染发剂的微核试验国外未获得肯定的阳性结果;国内尚未见到有关研究报道。我们参照Matter和Schmid等的微核试验方法,用“上海染发剂”对小鼠进引了微核试验。现将试验方法与主要结果报道如下: In recent years, due to the development of short-term biological tests, there are increasing studies on carcinogenic, mutagenic, and teratogenic effects of hair dyes in foreign countries. Scholars at the Chester Beatty Cancer Institute and the University of California have found that many hair dyes can damage the genetic DNA of S. typhimurium. The Ames laboratory concluded that 85% of oxidative hair dyes have mutagenic effects. However, the micronucleus test of hair dyes has not received positive results abroad; no studies have been reported in China. We refer to the micronucleus test methods of Matter and Schmid et al. and use the “Shanghai Hair Coloring Agent” to introduce micronucleus test into mice. The test method and main results are now reported as follows: