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Objective To evaluate the functional changes in parotid glands with gustatory stimulation pre versus post radiotherapy by using diffusion-weighted MR imaging (DWI).Methods A HIPAA-compliant waiver of authorization was granted by the institutional review board.A prospective study was conducted on 20 patients with nasopharyngeal carcinoma who got the intensity modulated radiation therapy (IMRT) from September 2009 to May 2011.