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Autophagy is an intracellular degradation process to clear up aggregated proteins or aging and damaged organelles.The Beclin1-Vps34-Atg14L complex is essential for autophagosome formation.However,how the complex formation is regulated is unclear.Here,we show that Dapper1 (Dpr1) acts as a critical regulator of the Beclin1-Vps34-Atg14L complex to promote autophagy.Dpr1 ablation in the central nervous system results in motor coordination defect and accumulation of p62 and ubiquitinated proteins.