Tunable degradation mode and rate of biodegradable metals with surface technologies

来源 :2015 Shanghai Thin Film Conference(2015上海薄膜国际会议) | 被引量 : 0次 | 上传用户:liyan19821021
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  Biodegradable metals(BMs)are metals expected to corrode gradually in vivo,with an appropriate host response elicited by released corrosion products,then dissolve completely upon fulfilling the mission to assist with tissue healing with no implant residues[1].To date,Mg and its alloys,Fe and its alloys,Zn and its alloys,Ca-based,Sr-based and Zn-based metallic glasses had been developed as new candidates as BM.Immediately after contacting the body fluid,the BM would be oxidized into metal cations following the anodic reaction.The generated electrons are consumed by a cathodic reaction corresponding to the water reduction for Mg-based BMs and the dissolved oxygen reduction for Fe-based BMs.The interface between the BM implant and the host always keeps a dynamic balance and the host-biodegradation-products-BM double interfaces change all the time until final biodegradation of the BM.Surface modification is one of the most effective ways not only to control the degradation behavior but also to improve the surface biocompatibility.The performance criteria of an ideal BM device should perfectly match the injured tissue reconstruction process in terms of providing temporary mechanical support mimicking the near-term performance of traditional metallic implants and completely dissolve in longer time frames with an appropriate degradation rate tolerable for the human body.For example,the reported Mg-based BMs completely degraded within several months and,a much faster loss of mechanical integrity,therefore surface coating could be used as a remedy to extend the mechanical integrity of Mg-based BMs.In the case of Fe-based BMs,they exhibit good mechanical support but slow degradation,therefore surface coating could be used to accelerate the biodegradation.In this talk,the recent works by the author will be presented to show how to realize the tunable control on the biodegradation mode and rate by various surface technologies.
其他文献
金属有机骨架(MOFs)材料是一类由有机配体和金属离子或金属团簇杂化而成的新型多孔材料,具有高的孔隙率、大比表面积等结构特点,被广泛的应用于气体分离、储氢及催化等方面。虽
  化疗是现在癌症疗法的一个重要组成部分,用于治疗大多数癌症。虽然近几年各种策略用于努力有效杀死癌细胞的药物传送系统已经开发,但其控制释放效果不好,往往造成严重不
会议
本文通过对荣华二采区10
期刊
氢能是一种非常清洁的可再生能源,较有可能取代传统的化石能源满足今后日益增长的能源需求。固体聚合物电解质(Solid Polymer Electrolyte,简称SPE)电解水制氢技术将制氢效率从传
该论文主要合成了香豆素120及其系列的7-取代三嗪氨基香豆素类化合物,3-(4-溴苯基)和3-(4-羟丙炔基苯基)取代香豆素类化合物.利用红外光谱仪、核磁共振仪、紫外光谱仪、荧光
纳米TiO2和ZnO颗粒的尺寸效应、表面效应、体积效应使其在光、电、磁、催化等方面表现出奇特的性能,可是,因为纳米颗粒比表面积大、比表面能高、表面活性也高,在分散的过程中纳
渣油中存在大量含硫有机物,主要是噻吩类、硫醚类等有机物.经过超临界水处理后,渣油可以获得良好的轻质化效果.但是,大量的硫、氮等元素仍然存在于轻质化产物中.在进一步的加
光催化技术始于二十世纪七十年代日本学者的重大发现。他们发现在光的照射下,二氧化钛可以催化分解水,从而产生氢气与氧气。这激发了人们的研究热情,于是研究人员将这种光催化的
该文研究了油脂氢化过程中使用的加氢催化剂.主要考察了以硅藻土、SiO为载体,Ni为主要活性成分的负载催化剂的制备过程和反应性能.对其制备过程中的还原温度、还原时间、Ni负
亚铁血红素氧化酶Ⅰ(heme oxygenasel,Hoxl)和藻蓝素铁氧还蛋白还原酶(ferredoxin oxidoreductase,PcyA)是藻蓝胆素(PCB)合成过程中的关键酶,它们表达的两个酶催化血红素(hem
学位