Bipartite Nuclear Localization Signal Controls Nuclear Import and DNA Binding Activity of Interferon

来源 :第十一届全国病毒学学术研讨会暨第六届武汉现代病毒学国际研讨会 | 被引量 : 0次 | 上传用户:djgohx
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  Accurate cellular localization plays a crucial role in the effective function of most signaling proteins and nuclear trafficking is central to the function of transcription factors.Here we focus on the nuclear-cytoplasmic shuttling of interferon regulatory factor 3(IRF3),an essential transcription factor responsible for the induction of type I interferon(IFN),which plays a crucial role in host antiviral innate immune responses.
其他文献
Hepatitis C virus (HCV) is a hepatotropic virus which causes chronic liver disease,belongs to Flaviviridae family including many highly pathogenic viruses.HCV can spread through two transmission pathw
会议
目的:了解山东省2011年一例急性驰缓性麻痹病例标本中分离到三株病毒的(脊髓灰质炎疫苗高变异株和柯萨奇病毒A4和A8病毒各一株)的基因特征,并对该病例接触者标本进行病原学鉴定及分析。方法:采集病例及40份接触者粪便标本进行病毒分离,对脊灰病毒进行全基因组序列测定和分析,对非脊灰肠道病毒进行VP1区序列测定,并将分离率较高的柯萨奇病毒(Coxsackievirus,CV)B1和CV-B3与国内外其他
目的:对2013年采自吉林地区养殖场的毒株编号为Ch-S-1的Ⅳ型HEV的全基因序列进行分析.方法:提取病毒RNA,采用RT-PCR方法分段扩增HEV全长基因,两端采用RACE法扩增,经过序列测定和拼接,利用ClusterX1.81、MEGA3.0、Phylop win 3.0软件分析基因序列.
Transmissible gastroenteritis virus(TGEV)is a member of Coronaviridae family.TGEV infection has emerged as a major cause of severe gastroenteritis and leads to alterations of many cellular processes.M
The host range of the pox virus is specific.Generally,Sheeppox virus (SPV) infects with sheep (Sheep) only and Goatpox virus (GPV) infects sheep and goats.The mechanism of the difference host range of
会议
Hepatitis C virus (HCV) nonstructural protein 5A (NS5A) is essential for HCV genome replication and virion production and is involved in the regulation of multiple host signaling pathways.As a proline
会议
Astrovirus (Astroviridae) is a positive single stranded RNA virus family that can infect humans and a wide variety of vertebrates,causing diseases ranging from gastroenteritis to fatal hepatitis,encep
会议
Enterovirus 71 (EV71) has played an important role in hand-foot-mouth disease.1,2 In this presentation,a series of diarylhydrazide analogues were designed and synthesized.A systematic exploration of S
会议
The novel avian-origin influenza type virus H7N9 was first identified in March 2013 in China and recently emerged again in the beginning of 2014.Similar to the influenza H5N1 virus infection,patients
会议
The major capsid protein (MCP) is the main immunogenic protein of iridoviruses,that has been widely used as an immunogen in vaccination trials.In this study,the codon-optimized giant salamander iridov
会议