<正>It continues to be a major challenge to the repair of central nervous system(CNS) damage.The olfactory system is the only region of the mammalian CNS in which the olfactory receptor neurons are unique in retaining their ability to regenerate throughout life,both in response to injury and as part of normal turnover.Olfactory ensheathing cells(OECs) are the glial cells that derive from the olfactory placode and envelop olfactory axons in the course of migration from the olfactory epithelium to the bulb.Owing to the axonal growth-promoting properties,OECs transplantation has emerged as a very promising experimental therapy to treat axonal injuries.Transplanted OECs have been shown to migrate with regenerating axons through an unfavorable CNS environment,and to mingle well with astrocytes in adult brain.Therefore, the migrating ability of OECs in CNS was thought to be essential for neural regeneration and re-ensheathment.However, little is known about the extracellular and intracellular factors that affect OEC migration.In present study,we report some factors involved in regulating the migration of OECs.This work might open new avenues for improving therapeutic properties of OECs on CNS injury and degeneration.