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  5. Gene expression profile of peripheral ganglion in diabetic and high-fat high-sugar diet resistant ra

Gene expression profile of peripheral ganglion in diabetic and high-fat high-sugar diet resistant ra

来源 :中国神经科学学会第九届全国学术会议暨第五届会员代表大会 | 被引量 : 0次 | 上传用户：adai1989
【摘 要】
：
Objective To screen and identify differentially expressed genes in peripheral ganglion in type 2 diabetic and high-fat high-sugar (HFHS) diet resistant rats.Methods We compared the differential gene e
【作 者】
：
Xiao-Li TANG Li-Bin DENG Fan-Jun KONG Jia-Ri LIN Shang-Dong LIANG 
【机 构】
：
Laboratory of Physiology, Medical college of Nanchang University, Nanchang 100038, China
【出 处】
：
中国神经科学学会第九届全国学术会议暨第五届会员代表大会
【发表日期】
：
2011年1期
【关键词】
：
type 2 diabetes mellitus peripheral ganglion gene expression Sprague Dawley rats 
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　　Objective To screen and identify differentially expressed genes in peripheral ganglion in type 2 diabetic and high-fat high-sugar (HFHS) diet resistant rats.Methods We compared the differential gene expression in 2 groups using Illumina(R) Sentrix(R) BeadChip arrays.Results (1) 158 out of 12 604 genes were differentially expressed.(2) GO analysis showed 4 and 2 biological processes were significant in high expressed genes of diabetic and resistant rats, respectively.(3) KEGG analysis showed 6 and 1 pathways were significant in high expressed genes of diabetic and resistant rats, respectively.Conclusion Muscle system process and response to biotic stimulus was involved in the process of diabetes and HFHS diet resistance.
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