【摘 要】
：
α-glucosidase plays an important role in the regulation of postprandial blood glucose levels, and its inhibitors, which can suppress postprandial hyperglycemia, are usually used to prevent or treat ty
【机 构】
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National Chromatographic R&A Center, Dalian Institute of Chemical Physics, the Chinese Academy of Sc
【出 处】
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第2届大连国际色谱学术报告会、第37届国际高效液相色谱及相关技术会议、第18届全国色谱学术报告会
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α-glucosidase plays an important role in the regulation of postprandial blood glucose levels, and its inhibitors, which can suppress postprandial hyperglycemia, are usually used to prevent or treat type Ⅱ diabetes.Although strong synthetic α-glucosidase inhibitors (i.e., acarbose) are available, they usually cause significantly adverse gastrointestinal events.For this reason, naturally α-glucosidase inhibitors, particularly those from the traditional Chinese medicines, have been explored as viable, low toxicity alternatives for treating type Ⅱ diabetes.More than 100 herbal medicines have been reported to show great potency in inhibiting the α-glucosidase activity, however, the therapeutic basis for most of them are still unidentified.So the major task is to develop a rapid, low-cost, and effective technique for enzyme inhibitor screening.
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