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  5. Upregulation of TRPM7 channels by angiotensin Ⅱ triggers phenotypic switching of vascular smooth mus

Upregulation of TRPM7 channels by angiotensin Ⅱ triggers phenotypic switching of vascular smooth mus

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：cjl11082009
【摘 要】
：
Aim: The present study was designed to explore whether the Ca2+-permeable transient receptor potential melastatin 7 (TRPM7) channel is involved in Ang Ⅱ-induced phenotype switching of ascending aortic
【作 者】
：
Zheng ZHANG Mi WANG Xiao-han FAN Jing-hui CHEN Yong-yuan GUAN Yong-bo TANG 
【机 构】
：
Department of Pharmacology,School of Pharmaceutical Sciences,Central South University,Changsha 41008
【出 处】
：
The 12th Meeting of the Asia Pacific Federation of Pharmacol
【发表日期】
：
2013年4期
【关键词】
：
angiotensin Ⅱ TRPM7 phenotypic modulation smooth muscle cell Ca2+ 
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Aim: The present study was designed to explore whether the Ca2+-permeable transient receptor potential melastatin 7 (TRPM7) channel is involved in Ang Ⅱ-induced phenotype switching of ascending aortic VSMCs, and to dissect the molecular mechanisms by which TRPM7 modulates VSMC phenotype.Methods: Whole-cell and single-channel patch damping was carried out to measure TRPM7 currents in mouse aortic smooth muscle cells.TRPM7-mediated Ca2+ entry was assessed by Fura-2/AM loading.
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