【摘 要】
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High mobility group box-1 (HMGB1),has been implicated as a pro-inflammatory cytokine in the pathogenesis of various inflammatory and autoimmune diseases.However,information about HMGB1 in Henoch-Sch(o
【机 构】
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Department of Dermatovenereology,West China Hospital of Sichuan University,Chengdu,610041,Sichuan,Ch
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High mobility group box-1 (HMGB1),has been implicated as a pro-inflammatory cytokine in the pathogenesis of various inflammatory and autoimmune diseases.However,information about HMGB1 in Henoch-Sch(o)nlein purpura (HSP) is still unknown.Herein,we investigated the role of HMGB1 in patients with HSP and the pro-inflammatory effects of HMGB1 on human dermal microvascular endothelial cell line (HMEC-1).Serum HMGB1 levels in patients with HSP,together with patients with allergic vasculitis (AV) and urticarial vasculitis (UV) were detected by enzyme-linked immunosorbent assay (ELISA).
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