Vascular endothelial cells (VECs) lining on the inner surface of blood vessels are constantly exposed to fluid shear stress generated by blood flow.This varying shear flow alone, or along with the presence of the adenosine triphosphate (ATP), gives rise to dynamic intracellular calcium response.The intracellular Ca2+ dynamics plays an important role on the VEC structure and function; thus, it is essential to understand the mechanisms of signal transduction and transmission from the shear stress to the Ca2+ response and build mathematical models to predict and modulate the Ca2+ behavior (Wong et al., 1995; Wiesner et al., 1997; Plank et al., 2006; Hu et al., 2008).