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Parkinsons disease (PD) is a common motor disorder in human.Degeneration of dopaminergic neurons in the substantia nigra is the cause of PD.After dopamine denervation,an over-activity of glutamatergic pathways has been implicated in the neuropathology in PD.One of the possible causes of cell death of dopaminergic neurons in PD is suggested to be glutamate-mediated excitocytotoxicity.The excitocytotoxic cell death is mainly mediated by ionotropic glutamate receptors,including N-methyl-D-aspartate (NMDA) receptors.Blockage of NMDA receptors is believed to have therapeutic values in treatments of PD.In the present study,unilateral 6-hydroxydoapmine-leisoned rats were employed as an animal model for the investigation of the efficacy of NR 1 specific siRNA (NR 1-siRNA) in neuroprotection and amelioration of the motor symptoms of PD.