【摘 要】
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Deficiency of cyclin-dependent kinase 5 (Cdk5) has been linked to the death of postmitotic cortical neurons during brain development.We now report that,in mouse cortical neurons,Cdk5 is capable of pho
【机 构】
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Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research , Institute of Neur
【出 处】
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华东地区第十四届实验动物科学学术交流会
论文部分内容阅读
Deficiency of cyclin-dependent kinase 5 (Cdk5) has been linked to the death of postmitotic cortical neurons during brain development.We now report that,in mouse cortical neurons,Cdk5 is capable of phosphorylating the transcription factor FOXO1 at Ser249 in vitro and in vivo.Cellular stresses resulting from extracellular stimulation by H2O2 or β-amyloid promote hyperactivation of Cdk5,FOXO1 nuclear export and inhibition of its downstream transcriptional activity.
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