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骨病是多发性骨髓瘤(MM)的重要临床表现之一,1,25(OH)2D3(VD3)在治疗骨病的同时,还具有抗血管新生的作用[1]。本实验目的是研究VD3对血管内皮生长因子(VEGF)诱导的人骨髓来源内皮细胞系HBME1的增殖、迁移、微血管形成的抑制作用,以便了解应用VD3治疗MM新的作用机制。材料和方法
Bone disease is one of the most important clinical manifestations of multiple myeloma (MM). 1,25 (OH) 2D3 (VD3) also plays an anti-angiogenic role in the treatment of bone disease [1]. The aim of this study was to investigate the inhibitory effect of VD3 on the proliferation, migration and microvessel formation of human bone marrow-derived endothelial cell line HBME1 induced by vascular endothelial growth factor (VEGF) in order to understand the new mechanism of action of VD3 in the treatment of MM. Materials and Method