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Introduction: The mechanisms that link obesity and CVDs remain elusive.Compelling evidence indicates that adipokines play an important role in obesity-related CVDs.Here,we found a new adipokine named family with sequence similarity 19,member A5(FAM19A5),a protein with unknown function that was predicted to be distantly related to the CC-chemokine family,and examined its function in neointima formation.We aimed to test whether FAM19A5 was involved in adipose-vessel crosstalk.