The Holliday junction(HJ)is a key intermediate during homologous recombination and DNA double-strand break repair.Timely HJ resolution by resolvases is critical for maintaining genome stability.
Ankyrin-G(AnkG),a highly enriched scaffold protein in the axon initial segment(AIS)of neurons,functions to maintain axonal polarity and the integrity of the AIS.At the AIS,AnkG regulates selective int
Platinum-based anticancer drugs usually bind to purine bases through covalent bonds to inhibit DNA replication and cause cell death.However,systemic toxicity and drug resistance frequently undermine t
Nanobody is a class of camelid-derived single-domain antibody that has many potential advantages over conventional antibody and has been utilized to develop new therapeutic strategies for cancer and o