【摘 要】
：
Increasing reports demonstrated that paraptosis was a novel non-apoptotic cell death triggered by a variety of stimuli.However, no similar phenomenon has be
【机 构】
：
State Key Laboratory of Biocontrol, School of Life Science, Sun Yat-sen University, 135 West Xingang
【出 处】
：
中国水产学会鱼病专业委员会第七次会员代表大会暨学术讨论会
论文部分内容阅读
Increasing reports demonstrated that paraptosis was a novel non-apoptotic cell death triggered by a variety of stimuli.However, no similar phenomenon has been reported in virus infection thus far.Here, using fluorescence microscopy, electron microscopy and biochemical assays, we found that Singapore grouper iridovirus (SGIV) infection in host (grouper spleen, GS) cells evoked cell death with paraptosis-like features, characterized by appearance of cytoplasmic vacuoles and distended endoplasmic reticulum in the absence of DNA fragmentation, apoptotic bodies and caspase activation.
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