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Polycomb Group (PcG) and trithorax group (trxG) proteins form multimeric protein complexes that regulate chromatin via histone modifications and modulation of nucleosome remodeling activities, targeted to specific cis-regulatory elements named PcG response elements (PREs).However, they can also dynamically bind to other genes and affect cell proliferation and differentiation in a wide variety of biological processes as well as induce various types of cancers when mis-expressed or mutated.