Inhibition of p70 S6 kinase(S6K1)activity induces autophagy through TAK1-mediated AMPK and JNK activ

来源 :江苏省畜牧兽医学会成立60周年庆典暨2015年学术年会 | 被引量 : 0次 | 上传用户:changaty
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  mTOR activation is known to suppress autophagy by phosphorylating ULK1 at S757 and deactivating its enzymatic activity.Here we report that feedback activation of the mTOR-PI3K pathway by two S6K1 inhibitors(PF-and A77 1726,the active metabolite of immunosuppressive drug leflunomide)or by S6K1 knockdown did not suppress but rather induced autophagy.
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