【摘 要】
：
Prostaglandin E2 (PGE2) plays important roles in regulation of adipose physiological functions such as lipolysis through its receptors (EPs).Among the four receptors for PGE2, EP3 receptor is highly e
【机 构】
：
Department of Physiology and Pathophysiology,Peking University Health Science Center,Beijing 100191,
【出 处】
：
International Conference for Physiological Sciences 2012(201
论文部分内容阅读
Prostaglandin E2 (PGE2) plays important roles in regulation of adipose physiological functions such as lipolysis through its receptors (EPs).Among the four receptors for PGE2, EP3 receptor is highly expressed in white adipose tissue (WAT), and its expression is reduced under diabetic condition.The current study aimed to investigate the impact of EP3 receptor on lipolysis in adipocyte and its underlying mechanisms.Within WAT, EP3 receptor is predominantly expressed in mature adipocyte.EP3R-/-mice exhibit increased body and WAT weight when compared with wild type (WT) mice.WAT of EP3R-/-mice show an increased lipolysis rate than that of WT mice with increased protein levels of ATGL and phosphor-perilipin A.EP3R agonist sulprostone inhibits lipolysis in cultured adipocytes.As a robust lipolytic substance, isoprenaline stimulates lipolysis in WT mice, and this lipolytic effect is facilitated in EP3R-/-mice.In support, sulprostone inhibits lsoprenaline-induced lipolysis.Sulprostone was further shown to suppress lipolysis by diminishing cAMP content, which can be reversed by activation of adenylatecyclase.In conclusion: EP3 receptor inhibits lipolysis of WAT via inhibition of cAMPPKA pathway and repression of lipolytic enzymes.EP3 receptor is a novel target for type 2 diabetes involving deregulated adipose function.
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