Mitchellenes A-C,sesquiterpenes isolated by Davies and co-workers from the Eremophila mitchellii in 2011,1 havedisplayed moderate antiplasmodial inhibitory activity(Figure 1).2 Structurally,they shared a common fused tetracyclicmuurolane skeleton embedded with seven or eight contiguous stereocenters.More interestingly,all neighboringbridgehead protons of these compounds are located at the same face except the C-4 proton,resulting in a torsionalstructure in space which makes them particularly challenging targets from chemical synthetic viewpoint.To our bestknowledge,synthesis of mitchellenes have not been reported to date.Recently,we have developed a Domino DoubleIntramolecular Diels-Alder strategy to construct the 6/6/5/5 fused tetracyclic skeleton of mitchellenes and accomplishedthe synthesis of 4-epi-hydromitchellene B(Scheme 1).