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Lipopolysaccharide (LPS) is associated with adverse developmental outcomes including embryonic resorption,fetal death,congenital teratogenesis and fetal growth retardation.Here,we explored the effects of maternal LPS exposure during pregnancy on tesficular development,steroidogenesis and spermatogenesis in male offspring.The pregnant mice were intraperitoneally injected with LPS (50 μg/kg)daily from gestational day (GD) 13 to GD17.