Objective: Single-incision Laparoscopic splenectomy (SILSp) now recognized for its improving cosmesis over conventional laparoscopic splenectomy in patients with normal and mildly enlarged spleens.However,SILSp with splenomegaly to liver cirrhosis and portal hypertension is still insufficient.Methods: From February 2011 to March 2012,6 cases with splenomegaly to liver cirrhosis and portal hypertension were performed SILSp.3 of them were underwent esophagogastric devascularization in total laparoscopy and 1 case in hand-assitant laparoscopic approach.Results: The mean operative time was 231min and mean blood loss was 425ml.All the patients were ambulation in 2 days after operation and the mean time of eat ranged 2-4 days.The hospital stays ranged 6-9 days.There were 1 case with pleural effusion and fever and1 case with blooding,which were cured with conservative managements.Esophageal and gastric varices were alleviated obviously in 4 cases by 2 years follow-up.Conclusions: SILSp is feasible for splenomegaly to liver cirrhosis and portal hypertension.