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Bidirectional promoters are shared promoter sequences between divergent gene pair(genes proximal to each other on opposite strands),and can regulate the genes in both directions.In the human genome,>10%of protein-coding genes are arranged head-to-head on opposite strands,with transcription start sites that are separated by <1,000 base pairs.Many transcription factor binding sites occur in the bidirectional promoters that influence the expression of 2 opposite genes.