【摘 要】
：
HECTD3 is an E3 ubiquitin ligase with unknown functions.We show that HECTD3 confers cancer cell resistance to cisplatin.To understand the molecular mechanisms, we performed a yeast-twohybrid analysis
【机 构】
：
Kunming Institute of Zoology, Chinese Academy of Sciences China
论文部分内容阅读
HECTD3 is an E3 ubiquitin ligase with unknown functions.We show that HECTD3 confers cancer cell resistance to cisplatin.To understand the molecular mechanisms, we performed a yeast-twohybrid analysis and identified MALT1 as a HECTD3 interacting protein.HECTD3 promotes MALT1 ubiquitination with non-degradative polyubiquitin chains by direct interacting with the MALT1 through its N-terminal DOC domain.HECTD3 does not target MALT1 for degradation but stabilize it.
其他文献
Brachytherapy seeds are made by sealing radionuclides in metal or other non-degradable material (resin or glass) and surgically implanted into the tumor tissue, showing some efficacy in clinic for sol
The management of gastric cancer in Japan is a little different from other countries for the following two major reasons.One is the availability of the S-l, and the other is the prevalent use of secon
Background: Lung cancers with mutations in the epidermal growth factor receptor (EGFR) gene respond well to treatment with EGFR inhibitors.Endobronchial ultrasound-guided transbronchial needle aspirat
Adeno-associated virus (AAV) vector has been successfully utilized as a therapeutic gene delivery vector in several human clinical trials.To optimize AAV vector for effective tumor gene therapy, sever
From Oct.2011, Institut Gustave Roussy (Pr Eggermont, CEO) launched an active collaboration in the cancer field with Chinese cancer hospitals/institutions, not only in scientific and clinical exchange
Stereotactic radiosurgery (SRS) and hypo-fractionated stereotactic radiotherapy (SRT) are highly precise and effective treatments for small metastatic brain tumors.SRS and SRT improve the local contro
In recent years, tumor-associated carbohydrate antigens (TACAs) abundantly expressed on the cancer cells surface in the forms of glycoprotein or glycolipid have emerged as novel and effective anti-tum
Introduction: There is increasing evidence that robotic assistance (RARS) could provide better intraoperative and short-term outcomes than traditional laparoscopic approach (LARS) to rectal cancer sur
Metabolic dysregulation have been considered to play an important role in cancer initiation and progression.The observed shift fi-om oxidative phosphorylation to increased glucose burning renders tumo
Cancer stem cells (CSCs) have received considerable attention.Accumulating evidence suggests that CSCs are responsible for tumor initiation and progression, drug resistance, and metastasis.Development