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目的:观察辛桂止痛栓对子宫腺肌病痛经的治疗作用。方法:采用小鼠热板法及催产素诱发的大鼠痛经模型,采用醋酸致小鼠腹腔毛细血管通透性增高实验及大鼠子宫内包埋塑料管模型,观察辛桂止痛栓的镇痛和抗炎作用。结果:辛桂止痛栓可延长热板法小鼠痛阈值,能显著延长催产素诱发的大鼠痛经扭体潜伏期,减少扭体发生次数,能明显降低醋酸致小鼠腹腔毛细血管通透性的增高,能降低异物所致子宫炎症肿胀度。结论:辛桂止痛栓具有较好的镇痛和抗炎作用,对子宫腺肌病痛经有一定的治疗作用。
Objective: To observe the therapeutic effect of Xin Gui Zhitong suppository on dysmenorrhea of adenomyosis. Methods: The mouse hot plate method and oxytocin-induced rat dysmenorrhea model, the use of acetic acid-induced increased peritoneal capillary permeability in mice and rat uterus embedded plastic tube model was observed Xin Gui analgesic analgesic And anti-inflammatory effect. Results: Xin Gui Zhitong suppository can prolong the pain threshold of hot-plate mouse, prolong the latent period of writhing induced by oxytocin, reduce the frequency of writhing, reduce the capillary permeability of mice induced by acetic acid Increased, can reduce foreign body swelling caused by inflammation of the uterus. Conclusion: Xin Gui Zhitong suppository has good analgesic and anti-inflammatory effects on dysmenorrhea of adenomyosis has a certain therapeutic effect.