人砷甲基化酶(hAS3MT)与甲基供体(SAM)结合位点的研究

来源 :第八届全国化学生物学学术会议 | 被引量 : 0次 | 上传用户：wdwd521

【摘要】

：

人砷甲基化酶(hAS3MT)和甲基供体(SAM)的结合位点可为探索无机砷(iAs)在hAS3MT人催化下的代谢机制提供有益信息.我们课题组曾根据多种与SAM相关的甲基化酶的序列对比分析,系

【作者】

：

李响利石楠王淑平耿志荣王志林

【机构】

：

南京大学化学化工学院,配位化学国家重点实验室南京市汉口路22号,210093

【出处】

：

第八届全国化学生物学学术会议

【发表日期】

：

2013年9期

【关键词】

：

hAS3MT SAM 氢键结合位点

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人砷甲基化酶(hAS3MT)和甲基供体(SAM)的结合位点可为探索无机砷(iAs)在hAS3MT人催化下的代谢机制提供有益信息.我们课题组曾根据多种与SAM相关的甲基化酶的序列对比分析,系统地研究了hAS3MT中四个酸性氨基酸残基(D76,D84,D102和D150)的功能及其与SAM的相互作用.

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人砷甲基化酶(hAS3MT)与甲基供体(SAM)结合位点的研究

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