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Simulations of the formation of multiple stellar populations in globular clusters predict that second-generation stars form in a compact subsystem in the cluster central regions.Previous studies have suggested that the initial differences in the structural properties of firstand second-generation stars can have significant implications for the evolution of the binary star population.We have performed a survey of N-body simulations to explore the evolution of binary stars in multiple-population globular clusters.We will presents results concerning the differences in the evolution of the global fraction of first-and second-generation binaries,the evolution of the binary spatial distribution,and of the binary binding energy distribution for clusters with different initial structural properties.