【摘 要】
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A DNA oligonucleotide with the sequence of 5-T1C2T3C4T5C6C7T8C9T10C11T12A13G14A15G16A17G18 was found to be able to form a paper-clip triplex.The structure s
【机 构】
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InstituteofChemistry,AcademiaSinica,Taipei,Taiwan11529
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A DNA oligonucleotide with the sequence of 5-T1C2T3C4T5C6C7T8C9T10C11T12A13G14A15G16A17G18 was found to be able to form a paper-clip triplex.The structure showed the C6C7/G18 apex base triad (in which C6C7 forms a tight tum structure,or,a folding structure without loop) is required for the intramolecular triplex formation (Biochemistry,39,12457-12464 (2000) and Biophys.J.,82,3170 (2002)).The C6C7/G18 apex base triad was also found in an intermolecular triplex formed by mixing of 5-T1C2T3C4T5C6C7T8C9T10C11T12-3 and 5-A13G14A15G16A17G18-3 (Biophys.J.,91,2552-2563).In other words,a triplex with C6C7 tight turn,similar to that of paperclip triplex,was formed.These two studies established the existence of tight tum structure.It is a new finding in DNA structure.
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