Sepsis is a global major health problem in great need for more effective therapy.For thousands of years, Rhubarb had been used for various disease including severe infection.Pharmacological studies and trials reported that may be effective in treating sepsis.But there is no systematic review on Rhubarb for sepsis.27 studies were identified from 7 databases to evaluate the efficacy and potential mechanisms of Rhubarb therapy for sepsis.Rhubarb has been apparent reported to be effective in reducing injuries induced by sepsis.Yet the positive findings should be interpreted with cautions due to poor methodological quality.