Excess mitochondrial stress and/or mitochondrial dysfunction are implicated in the development of neurodegenerative disease such as Parkinsons disease.Damaged mitochondria can be selectively eliminated by autophagy in a process called mitophagy.Although two gene products mutated in familial Parkinsons disease, Parkin and PINK1, have been found to play a central role in eliminating the damaged mitochondria through mitophagy machinery, how the pre-autophagosomal membrane selectively and accurately engulfs damaged mitochondria remains unclear.