Recent discoveries in seashells unveil that nature uses multiscale design strategies to achieve exceptional mechanical properties which are still beyond the reach of many engineering materials.The multiscale hierarchical structure,ranging from micro lamellae down to nanoparticles,renders seashells multilevel strengthening and toughening mechanisms such as crack deflection,interlocking,lamellaes deformability,biopolymers viscosity,nanoparticle rotation,deformation twining in nanoparticles,and amorphization,jointly contributing to seashells ultra-high mechanical robustness.To realize natures performance in engineering materials,we need to natures multiscale design and manufacturing strategies.This talk will present several case studies in which natures multiscale design strategies and materials selection principles are applied through manufacturing.The presentation is entirely from the previously published papers.