One of the best solutions for meeting future energy demands is the conversion of water into hydrogen fuelusing solar energy.The splitting of water into molecular hydrogen(H2) and oxygen(O2) using light involvestwo half-reactions:the oxidation of water to O2 and the reduction of protons to H2.To take advantage of thefull range of the solar spectrum,researchers have extensively investigated artificial photosynthesis systemsconsisting of two photosensitizers and two catalysts with a Z-configuration:one photosensitizer-catalyst pairfor H2 evolution and the other for O2 evolution.This report reviews advances our laboratory has made in thedevelopment of new systems for photocatalytic H2 evolution that uses earth-abundant materials and is bothefficient and durable.We constructed several assemblies of CdTe and CdSe QDs as photosensitizers with[FeFe]-H2ase mimics as catalysts.