Purpose: ORMl-like 3 (ORMDL3) belongs to a highly conserved protein family, which is anchored as transmembrane proteins in the endoplasmic reticulum.Gasdermin B (GSDMB) is adjacent to ORMDL3 on chromosome 17q21.2 and belongs to the gasdermin-domain containing protein family (GSDM family).Recent reports suggest that GSDMB and ORMDL3 are associated with asthma in several populations.However, genetic association studies that examined the association between GSDMB and ORMDL3 gene variants and asthma showed conflicting results.To assess whether combined evidence shows the association between GSDMB and ORMDL3 polymorphism and asthma.