Functional and phenotypic diversity of leukemia-associated macrophages in response to the microenvir

来源 :2014天津国际干细胞论坛 | 被引量 : 0次 | 上传用户:liuxuedong0628
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Tumor-associated macrophages (TAMs) are widely studied in solid tumors.The distribution of macrophages in lymph node samples was found to be associated with prognosis in lymphomas.
其他文献
目的:探讨染色体结构异常携带者孕妇的妊娠生育风险及遗传咨询要点.方法:对22例夫妻一方为染色体结构异常携带者的孕妇进行羊水穿刺及胎儿染色体核型分析,并对妊娠结局进行随访.结果:22例携带者中女性20例,男性2例,其中平衡易位携带者14例,占63.6%;罗伯逊易位携带者6例,占27.3%;臂间倒位2例,占9.1%.胎儿染色体核型结果正常7例(1例1qh+划入正常范围),占31.8%;易位及倒位携带者
会议
杂合性缺失(Loss of heterozygosity, LOH)指某个基因座上的一个等位基因出现杂合缺失,或两个等位基因来自同一个亲本所导致的纯合现象.杂合性缺失大多数临床意义不明,但需警惕该区域内隐性遗传基因、印记基因的致病风险.当患者出现与该区域内隐性遗传基因、印记基因相关的临床表型时,需对相应的基因作进一步检测.地中海贫血(简称地贫,Thalassemia),是一种常染色体隐性遗传溶血性
会议
目的:探讨一种新的基于CNVplex技术的高效耳聋基因筛查平台的临床应用实践.方法:(1)采用CNVplex技术,选择非综合征耳聋(Non-syndromic hearing loss,NSHL)患者中突变率达60%以上的GJB2、SLC26A4、mt-DNA三个基因在中国人群中报道的115个突变型(其中GJB2基因36种突变型,SLC26A4基因77种突变型,mt-DNA基因2种突变型),通过常
会议
目的 探讨多重连接依赖式探针扩增(Multiplex ligation-dependent probe amplification,MLPA)技术性在临床上检测先天性心脏病(congenital heart defects,CHDs)患者基因拷贝数变异(Copy number variation,CNV)的可行性,了解中国未挑选的先天性心脏病患儿中基因拷贝数变异的发生情况.方法 收集未挑选的125
会议
目的:遗传性多发性骨软骨瘤(hereditary multiple exostoses,MO),是一种骨胳发育异常,在骨胳上可形成大小不等的骨隆起的常染色体显性遗传性疾病.本研究利用一个多发性遗传性骨软骨瘤大家系进行致病基因的突变鉴定.方法:遵守知情同意原则,采集到1个6代家系共计25份外周血标本,其中患者18人,正常个体7人,涉及三代.明确患病表型和临床诊断,分别在已知EXT1,EXT2致病候选
会议
In mammals,mTOR is the key component of two distinct multi-protein complexes,mTOR complex 1 (mTORC1) and 2 (mTORC2).mTORC2 is insensitive to rapamycin and includes mTOR,Rictor,mLST8,mSin1,Protor-1,and
会议
How glucose is metabolized can influence cell function,but whether differences in energy metabolism reflect,or dictate,cell state is not clear and is of particular interest given the association of ca
会议
New clinical trial results and the application of deep sequencing have generated new insights into the pathophysiology of severe aplastic anemia (SAA).Eltrombopag,a thrombopoietin mimetic that acts on
会议
Recent efforts in cancer genome sequencing have identified mutations in numerous histone modifying genes,yet the epigenetic mechanisms as a driving force in cancer development remain to be elucidated.
会议
Aplastic anemia (AA) is a rare and severe blood disease.Its incidence varies considerably worldwide,ranging from 4 to 20 per million people.Previous studies have demonstrated that most acquired AA is
会议