Objective UbcH10 is the cancer-related E2 ubiquitin-conjugating enzyme.In ubiquitin-proteasome system,ubiquitin-conjugating enzyme (E2) together with ubiquitin ligase (E3) transfers ubiquitin to the specific substrate protein.The ubiquitin-proteasome system plays a pivotal role in protein homeostasis and is critical in regulating normal and cancer-related cellular processes.UbcH10 is not only one important member of ubiquitin-proteasome system,but also one of the key regulators of cell cycle progression.