ObjectiveThe tissue defects and cica-contracture on face and neck are severe disaster for the patients functions and appearances.The repair and reconstruction is very important.There are multiple and stable blood supply systems on face, neck and thoracic skin, which are the suitable donor sites for the skin flaps.In this study, the repair of tissue defects on face and neck using Single or multiple island skin flaps with multiple blood supply system was explored.Methods From Jan 2006, 108 cases with severe tissue defects on face and neck were repaired using island skin flaps with multiple blood supply systems.The skin flaps were pedicled by cutaneous branch of cervical segment of transverse artery,intercostal branch of internal thoracic artery, lateral thoracic artery, and others respectively.Results All the skin flaps were survive except a skin flap pedicled by cutaneous branch of cervical segment of transverse artery with a small epidermal blain on the distant part, which were healed after simple dressing changes.The functions and configurations were satisfactory after six months to five years follow-up.Conclusion Transplantation of island skin flap with multiple blood supply system is an ideal method to repair the tissue defects on face and neck according to the patients demand, the whole body situation, defect location and range.