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  5. PyMut: a web tool for overlapping gene loss-of-function mutation design

PyMut: a web tool for overlapping gene loss-of-function mutation design

来源 :第六届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会 | 被引量 : 0次 | 上传用户：yinxiaomei
【摘 要】
：
Loss-of-function study is an effective approach to research gene functions.However, currently most of such studies have ignored an important problem (in this paper, we call it "off-target" problem), t
【作 者】
：
刘珂 孙之荣 
【机 构】
：
生物信息学教育部重点实验室,生命科学学院,清华大学,北京,100084
【出 处】
：
第六届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会
【发表日期】
：
2014年4期
【关键词】
：
overlapping gene design yeast python 
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　　Loss-of-function study is an effective approach to research gene functions.However, currently most of such studies have ignored an important problem (in this paper, we call it "off-target" problem), that is, if the target gene is an overlapping gene (A gene whose expressible nucleotides overlaps with that of another one), loss-of-function mutation by deleting the complete open reading frame (ORF) may also cause the gene it overlaps partially (or totally) lose functions, resulting a phenotype which is rather different from that of single gene mutation.
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