【摘 要】
：
Objectives Recent studies have demonstrated that antidepressant effect of N-Methyl-D-aspartate (NMDA) antagonist ketamine activates rapidly the mammalian target of rapamycin (mTOR) pathway and increas
【机 构】
：
Paik Institute for Clinical Research,Inje University,Busan,Republic of Korea
【出 处】
：
中华医学会第十一次全国精神医学学术会议暨第三届亚洲神经精神药理学术会议
论文部分内容阅读
Objectives Recent studies have demonstrated that antidepressant effect of N-Methyl-D-aspartate (NMDA) antagonist ketamine activates rapidly the mammalian target of rapamycin (mTOR) pathway and increase synaptic proteins the prefrontal cortex.mTOR is a protein kinase involved in the regulation of translation initiation and protein synthesis required for synaptic plasticity.Recent studies suggest that mTOR activation may be related to the antidepressant action.However,the mTOR signaling underlying antidepressant drugs action has not been well elucidated.The aim of the present study was to find out whether alterations in mTOR signaling could be observed following treatment with tianeptine.Additionally,we investigate whether this drug affect the synaptic proteins and neurite outgrowth via mTOR signaling.
其他文献
Objectives Neuregulin-1 (NRG1) is implicated in the etiology or neuropathology of various psychiatric diseases such as schizophrenia and major depression,although its biological contribution to the in
Lithium,a direct inhibitor of glycogen synthase kinase 3 (GSK-3),has been widely prescribed mood stabilizer in treatment of bipolar disorder.Evidence suggests that lithium affects monocytic cells,whic
Objectives Bipolar disorder is a devastating illness that is characterized by cycling periods of mania and depression.Conversing lines of evidences indicate that mood disorders,including bipolar disor
Objectives Several postmortem studies have noted decreased expression of genes responsible for synaptic proteins in the prefrontal cortex (PFC) and other regions,suggesting impairment or reduction in
Objectives The alteration of hippocampal plasticity has been proposed to play a critical role in both the pathophysiology and the treatment of depression.In this study,the ability of different classes
Background The efficacy and safety of olanzapine monotherapy are evaluated in Japanese patients from a larger,global study of bipolar depression.
Objectives Mammalian target ofrapamycin (mTOR) is a protein kinase involved in the regulation of translation initiation and protein synthesis required for synaptic plasticity.Recent studies suggest th
目的 研究布南色林片单次给药后的人体药代动力学.方法 经广州市脑科医院伦理委员会审批通过,招募30例健康志愿者并分为3组,每组10人,男女各半,分别单次口服4 mg、8 mg和12 mg布南色林片后,采集0、0.25、0.5、0.75、1、1.5、2、3、4、6、8、12、24、36、48和60 h内动态血标本,采用HPLC-MS/MS测定血浆中布南色林的浓度,最后用DAS 3.2.4软件对试验数
目的 探讨精神分裂症患者智力和记忆、持续注意、执行功能之间的关系,以便更加准确的理解精神分裂症患者智力的真实情况.方法 选取符合国际疾病分类标准第十版(ICD-10)之相应诊断标准的住院精神分裂症患者120例(男56例,女64例,平均年龄(35.91±12.02)岁;平均发病年龄(26.46±7.59)岁;平均病程(9.29±9.47)年;平均受教育年限(13.04±3.01)年)及60例健康正常
Objective Mirtazapine,an antagonist for central α2-adrenergic autoreceptors and heteroreceptors,and postsynaptic 5-hydroxytryptamine2 (5-HT2) and 5-HT3 receptors,achieves its unique therapeutic effect