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ObjectivesTo describe PK profiles of CPZ/SUL in HAP patients induced by multidrug-resistant (MDR) P.aeruginosa and Acinetobacter spp.To identify and quantify the covariate effects on the PK profile of cefoperazone To characterize the relationship of CPZ/SUL PK exposures coupled with PD covariates to the clinic and bacteriology responses with PK/PD model To evaluate therapeutic regimens of CPZ/SUL in the HAP patients caused by Acinetobacter spp.and P.aeruginosa