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Background The revolutionary concept of utilizing antiproliferative drugs with improved lipophilicity and polymer coatings that biodegrade in the design of drug-eluting stents (DES) has led to the development of biodegradable polymer stents eluting sirolimus and its analogues.We aimed to systematically review the current randomized evidence on their efficacy and safety profiles,and to investigate if there are differences in clinical effects among these biodegradable polymer "limus" eluting stents.