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Titanium dioxide nanoparticleswhich are well known with their photocatalytic activity have become one of the most potential nanomaterialsapplied in environmental scientific research and clinical exploring fields.To evaluate the effect of drug delivery carrier role of titanium dioxide nanoparticles combined with anticancer drug,daunorubicin.on cancer cells.fluorescence microscopy.MTT and FCM assay have been explored in this study.Our observations demonstrate that compared with the effect of daunorubicin alone,the intracellular concentrations of daunorubicin in cancer cells like liver SMMC-7721 cancer ceils obviously increase in the presence of titanium dioxide nanoparticles.Besides,it is observed that the ultra violent illumination can further enhance the lethality of cancer cells.These results indicate that the titanium dioxide nanoparticles can act as an efficient carrier for drug delivery to increase the uptake of drugs and hence lessen the toxic side effects.Thus.it is evident that this new combination of titanium dioxide nanoparticles and anticancer drugs could be utilized as an optimal strategy for their promising biomedical application in cancer therapy.