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Background: Fatigue and anemia are adverse conditions related both to disease and treatment in cancer patients.We previously showed (ESMO2012, lecture 15450) that these conditions were separately able
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Background: Fatigue and anemia are adverse conditions related both to disease and treatment in cancer patients.We previously showed (ESMO2012, lecture 15450) that these conditions were separately able to discriminate patients in "Good", "Intermediate" and "Poor" risk groups.But the joint impact of these two conditions had not been studied so far and will be addressed in this presentation.Methods: pts included in a toxicity anticipating program (blood samples and patient reported outcomes) between 2008 and 2011 at the HEGP hospital (Paris, France).Fatigue was graded according to CTC-NCI: 0=none, 1=mild, 2=moderate, 3=severe, 4=3+long-term condition and anemia from normal to life threatening.Fatigue and anemia scores were calculated as weighted means over the whole chemotherapy period.Cox regression was used to calculate risk of death given: age, tumor localization, disease setting and continuous or categorized scores.Internal validation with 1000 bootstrap samples and external validation were performed.Results: 1279 pts entered this program, 661 had at least 1 of fatigue and hemoglobin assessments.Median age=64.9y, sex-ratio=1.1, more frequent localization (%): lung: 25, breast: 21, urogenital:21, gynecological: 13, ENT: 12.OS (m, 95%CI) was 27.8 (26.2-29.4).Median follow-up was 26.7m (25.5-27.9).The presentation will discuss new results demonstrating the negative joint impact of these conditions and recommendations for clinicians to correct both fatigue and anemia as soon as possible.Conclusion: This study confirmed the additive negative impact of fatigue and anemia in cancer patients.
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