The victims radiated by high-dose in a short time are often accompanied by symptoms of systemic reaction,such as systemic inflammation,nausea,slower growth and so on.X-ray exposure produce persistent difficulties in memory through an unknown mechanism.Insulin-like growth factor 1 (IGF-1),a protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development.Here,in order to study the relationship between IGF-1 expression pattern and X-ray exposure in brain of Tibet Minipigs,not castrated male Tibetan minipig were chose as animal model,and exposed to the total body X-ray radiation at 0 and 10 Gy.