Dorsal Premotor Area of the Macaque Monkey Encodes Internal Grasp Movement Planning

来源 :第九届海内外华人神经科学家研讨会(The 9th Symposium for Chinese Neuroscientis | 被引量 : 0次 | 上传用户:flyingmomo1986
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  Recently,some studies demonstrated that neuron activity of the dorsal premotor cortex(PMd)showed selectivity for different hand gestures during planning period,which suggested that PMd is involved not only in arm reaching but also in hand grasping.However,it is difficult to identify whether the neuron selectivity results from visual cues related to object shapes or hand preshapes because different objects were asked to be grasped by using specific gestures in their experiments.In this study,we designed a free-choice task where a monkey was trained to autonomously choose one of two gestures(Power or Hook)to grasp the same object after a holding period for planning.Neural signals of PMd were collected by microelectrode array when the monkey was performing the task.With single unit activity analysis,we found that 18%(45/250)of units in PMd showed significant difference for the two gestures during movement planning period.In some of these units,the selectivity of their neuron activity disappeared immediately after the movement onset.We further examined the selectivity of neural activity on the neuron population level with a support vector machine(SVM)classifier.The gesture classification accuracy obtained from the neural activity of these tuning neuron subset could reach up to 93.5%during the planning period.Our results infer that the selectivity of partial PMd neurons during the planning period of grasp movements was closely related to the internal action selection or movement preparation rather than the external visual cues such as size or orientation of target objects.
其他文献
Prompt reperfusion after cerebral ischemia is critical for neuronal survival.Any strategies extend the limited reperfusion window will be of great importance.Acidosis postconditioning(APC)is a mild ac
Subcortical ischemic vascular dementia(SIVD)caused by chronic cerebral hypoperfusion exhibits progressive white matter and cognitive impairments.However,its pathogenetic mechanisms are poorly understo
会议
Stroke is the fifth leading cause of death for Americans,and about 87%of all strokes are ischemic strokes.Astrogliosis plays a crucial role in the pathophysiology of delayed neuronal death(DND)followi
The pathophysiologic mechanisms of epileptogenesis are still poorly understood and there was still no effective therapy available to suppress epileptogenesis.Significant β-nicotinamide adenine dinucle
Dopamine(DA)is essential for both physiological and behavioral responses including the regulation of sexuality.Previous studies have revealed that activity of PPL2ab neurons enhances male courtship su
Sensory inputs engage selective responses in cortical neurons to generate the representation of the external world.However,the way that such selectivity is formed and modified by experience is largely
Background There are many different ways to depict fear circuits,such as lesions,electrical stimulation,retrograde labeling,whole-cell patch-clamp recording,functional magnetic resonance(fMRI)and posi
Information about translations and rotations of the body is critical for complex selfmotion perception during spatial navigation.However,little is known about the nature and function of their converge
Neurotoxins are harmful to brain functions,especially interrupting memory processing.Hippocampal synaptic plasticity is supposed as models for memory processing.We and others reported the potential de
Papermulberry fruit is commonly used for patients with chronic cerebral circulatoryinsufficiency(CCCI),which has the function of the tonifying liver and kidney.The present study focused on the efficac